Humanized Anti-CD28 Recombinant Antibody (clone Lulizumab)
CAT#: TAB-H46
This product is a humanized V-kappa antibody that can recognize human CD28.
Tested Data
Gene Expression
SDS-PAGE
Figure 1 Humanized Anti-CD28 Recombinant Antibody (TAB-H46) in SDS-PAGE
SDS-PAGE analysis of TAB-H46 in non-reduced (Lane 1) and reduced (Lane 2) conditions.
The purity of TAB-H46 was greater than 95% as determined by SDS-PAGE.
SEC-HPLC
Figure 2 Humanized Anti-CD28 Recombinant Antibody (TAB-H46) in HPLC
The purity of TAB-H46 was greater than 95% as determined by SEC-HPLC.
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Normal Tissue
Figure 1 Lymph node
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_9_8.jpg
Normal Tissue
Figure 2 Tonsil
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/70003/161787_A_6_8.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000178562-CD28
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized V-kappa
- Specificity
- Human CD28
- Species Reactivity
- Human
- Clone
- Lulizumab
- Applications
- IP, IF, FuncS, FC, Neut, ELISA, IHC
Product Property
- Purification
- Affinity Purified
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Immunoprecipitation, Immunofluorescence, Functional Assay, Flow Cytometry, Neutralization, Enzyme-linked Immunosorbent Assay, Immunohistochemistry.
Target
REVIEWS AND Q&AS
CITATIONS
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Antigen-Specific Responses
Lulizumab has been crucial in studying antigen-specific T-cell responses. It helps understand how CD28 co-stimulation influences T-cell responses to specific antigens, aiding targeted immunotherapy research.
Advanced Metabolic Studies
Lulizumab has facilitated detailed studies on T-cell metabolism. Engaging CD28 allowed us to explore metabolic pathways crucial for T-cell function and proliferation.
Crucial for Autoimmune Research
Lulizumab has been essential in our autoimmune disease research. It helped explore CD28 signaling's role in autoimmunity, providing valuable insights into disease mechanisms.
Q&As
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In what ways does lulizumab advance our understanding of T-cell metabolism?
A: By engaging CD28, Lulizumab enables researchers to investigate metabolic shifts in T-cells during activation, shedding light on the metabolic pathways crucial for T-cell function and proliferation.
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Which extra safety measures need to be taken when working with lulizumab in a laboratory setting?
A: Handle the antibody gently to maintain its integrity. Store aliquots at -20°C or lower, and protect from prolonged exposure to light to preserve its functional activity.
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Is it possible to use lollisumab for T-cell analysis using flow cytometry?
A: Lulizumab can be used in flow cytometry to detect CD28 expression on T-cells.
View the frequently asked questions answered by Creative Biolabs Support.
Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-H46, RRID: AB_3112033)
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Biosimilar Overview
Please refer to Lulizumab Pegol Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Lulizumab Pegol.
Related Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| TAB-065LC | Human Anti-CD28 Recombinant Antibody (TAB-065LC) | ELISA | Human IgG, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| HPAB-0246-FY | Mouse Anti-CD28 Recombinant Antibody (HPAB-0246-FY) | FC, FuncS, ICC, IHC, IP, WB | Mouse IgG1 |
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|---|---|---|---|
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|---|---|---|---|
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| VS-0724-XY11 | Rat Anti-Cd28 Agonistic Antibody (VS-0724-XY11) | FC, Agonistic assays, CyTOF® | Rat IgG1 |
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